2026 NFL Week 1 Opening Odds: Betting Lines, Spreads, and Top Matchups

The wait is officially over. Sportsbooks and prediction markets across the continent have released opening odds for Week 1 of the 2026 NFL regular season, giving bettors and football fans their first look at point spreads, moneyline prices, and totals across the full 16-game slate.

From marquee primetime showdowns to heated divisional clashes, Week 1 features compelling betting angles from top to bottom. The slate kicks off with a rare Wednesday opener – that’s also a Super Bowl 60 rematch – and rolls through Thursday night before a loaded 13-game Sunday schedule and a Monday night finale.

The table below lists the complete odds for all 16 matchups in Week 1 (in chronological order).

The 2026 campaign kicks off in Seattle with an intriguing interconference matchup on Wednesday, September 9th. DraftKings opens the defending Super Bowl-champ Seahawks as 3.5-point home favorites (-105) with a moneyline price of -185, while the visiting Patriots – the team Seattle beat in last year’s title game – sit as +3.5 underdogs (-115) and +154 to win outright.

The total is listed at 44.5 points, with slight juice to the Under (-115), indicating oddsmakers expect a physical, field-position battle early in the year as both units shake off offseason rust. Seattle won the 2026 Super Bowl 29-13 (42 total points) but the teams combined for just 12 points in the first three quarters.

Seattle opens the season as the fourth-favorite in the Super Bowl 61 odds, trailing the division-rival Rams (+550) plus a pair of AFC powers: the Bills (+1000) and Ravens (+1000).

Speaking of the Rams, the favorites for the Lombardi Trophy open the new campaign on Thursday night in a high-stakes NFC West clash with the San Francisco 49ers at SoFi Stadium. The first TNF odds of the season install the Rams as 3.5-point home favorites (-108) with a -185 moneyline, while the 49ers come in catching the hook at +3.5 (-112) and +154 on the moneyline.

The total of 48.5 points is among the highest on the Week 1 slate, signaling confidence in both offensive schemes to find early-season rhythm. Bettors siding with San Francisco will appreciate landing more than a field goal in a matchup that routinely comes down to the final possession.

Week 1 wraps with an intense AFC West showdown at Arrowhead Stadium between the Kansas City Chiefs and Denver Broncos. Kansas City enters as a 3.0-point home favorite (+100) with a -148 moneyline, while Denver travels as a +3.0 underdog (-120) and +124 on the moneyline.

The flat three-point spread with extra juice on Denver’s side highlights respect for the Broncos’ defense against a KC team that might not have Patrick Mahomes operating at 100%. With a total set at 42.5 points, sportsbooks anticipate a tight, grind-it-out divisional battle where every point in the fourth quarter will matter.