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New York Giants vs Los Angeles Rams betting tips, bet builder predictions

Get expert NFL betting tips for New York Giants vs Los Angeles Rams. Match preview, TV details, and a 7-1 Bet Builder for Monday night's game at SoFi Stadium.
New York Giants vs Los Angeles Rams betting tips, bet builder predictions

Date Tuesday, September 21Starts 1.15am BST (Monday night)Venue SoFi Stadium, Los Angeles, CaliforniaTV Sky Sports NFL & Sky Sports Main Event & NFL Game Pass via DAZN

The last game of Week Two in the NFL sees Super Bowl favourites the Los Angeles Rams attempting to redeem their reputation when they host the New York Giants at SoFi Stadium on Monday night.

The Rams were all the rage in the off-season and went off as clear market leaders but they flopped miserably in their first game as they were thrashed 27-7 by their NFC West rivals the San Francisco 49ers in Melbourne.

The unusual circumstances of playing the NFL's first regular-season game in Australia mean that result may not be worth taking at face value as the Rams' questionable decision to arrive the day before the game backfired spectacularly, but they also have some injury issues to deal with.

The Giants, meanwhile, made a promising start as they beat their NFC East rivals the Dallas Cowboys 28-20 in Week One, and they should head west in confident mood.

We've put together a four-leg bet builder for Monday night's game that includes a touchdown scorer fancy and three player prop bets which pays 27-4 with bet365.

New York Giants vs Los Angeles Rams

Tuesday, September 21, 1.15am

Kyren Williams to score a touchdown

Cam Skattebo over 50.5 rushing yards

Malik Nabers over 65.5 receiving yards

Nate Landman over 6.5 tackles and assists

Player tackles and assists

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The Rams put in a dreadful first performance in Australia, but dependable Kyren Williams still managed to get in the end zone for their only touchdown of the game and he can add to his tally back in their home stadium.

Williams also scored in all three of the Rams' playoff games last season so he is on a four-game scoring streak. Cowboys running back Javonte Williams scored rushing and receiving touchdowns against the Giants in Week One, so the signs are good for Williams to extend his run.

Cam Skattebo is one of the most colourful characters in the NFL and the old-school running back should let the Rams know he is on the field. Skattebo began the year with 81 rushing yards and a touchdown from 18 carries against the Cowboys, and he is one of the hardest players in the league to bring down when he gets a head of steam up.

The 49ers had 174 rushing yards against the Rams last week, with Christian McCaffrey and Kaelon Black each reaching the 65-yard mark.

Giants wide receiver Malik Nabers (right)Credit: Getty Images

Malik Nabers is one of the most talented wide receivers in the league and the Giants star made a promising return against the Cowboys with six receptions for 69 yards after missing the majority of last season with a knee injury.

With any concerns about his fitness now dismissed, he looks ready to become a key player for his team again and he could make some big plays after three 49ers wide receivers scored TDs against the Rams in the opening week.

Rams linebacker Nate Landman has overcome an injury worry to be available for this game and he could be in for a busy night with the Giants looking to run the ball through Skattebo.

He is a tackling machine and after having eight tackles and assists against San Francisco, he should be in line for seven or more on Monday night.

Odds correct at time of publishing

Giants vs Rams is scheduled to kick off at 1.15am BST on Tuesday, September 22 (Monday night) in the UK and Ireland.

Giants vs Rams will be played at SoFi Stadium in Inglewood, California.

Sky Sports is showing the game live in the UK on Sky Sports NFL and Sky Sports Main Event and it can be streamed on NFL Game Pass via DAZN (subscription required).

The Rams are the 20-63 favourites and the Giants are 51-20 with bet365.

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It was published on September 20, 2026 and last updated on October 9, 2026. The time of the story is shown in your own time zone on the page.

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