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Will Myles Garrett play against San Francisco 49ers tonight? Latest injury update on the Los Angeles Rams' linebacker

Myles Garrett is expected to play in the Los Angeles Rams’ season opener against the San Francisco 49ers in Melbourne, Australia. The star defensive end is set to make his Rams debut after joining a revamped defense that also features Trent McDuffie and Jaylen Watson.
Will Myles Garrett play against San Francisco 49ers tonight? Latest injury update on the Los Angeles Rams' linebacker

Myles Garrett (Image via: Getty)

The Los Angeles Rams are about to open a new chapter with Myles Garrett, and the setting could hardly be bigger. Garrett is set to make his Rams debut against the San Francisco 49ers in Melbourne, Australia, giving fans an early look at what the blockbuster defensive addition can bring. His first game in Los Angeles colors also comes in a rivalry that rarely lacks drama.

Yes, Myles Garrett is expected to play against the San Francisco 49ers tonight.Garrett is scheduled to make his first appearance for the Rams when the NFC West rivals meet at the Melbourne Cricket Ground. The matchup gives him an immediate test against one of the league’s most established offensive teams.His presence could quickly become one of the biggest storylines of the game. Garrett is known for his speed, strength and ability to disrupt quarterbacks, and Los Angeles will rely on those traits as it begins a new season with major expectations.The Rams have also added Trent McDuffie and Jaylen Watson to their revamped defense. Garrett, however, remains the centerpiece of that group. His debut will show how quickly he can fit into Sean McVay’s defensive plans and how much pressure he can create alongside Byron Young.

Garrett understands that the first assignment carries extra weight.“I don’t think there’s any right way to do it,” said defensive end Myles Garrett, who will make his Rams debut in Australia. “They have a plan, and I’m sure they consulted different teams and people to find out a way to combat jet lag and such long travel. We’ve done the same thing. I think we’re both riding our methodologies.”The comment also reflects the unusual circumstances surrounding this game. Both teams have traveled roughly 16 hours to Australia, but they chose very different ways to prepare.

There is no indication in the provided injury information that Garrett is dealing with an issue that will keep him out. Instead, all signs point toward the former defensive star taking the field for his first game with Los Angeles.The bigger challenge could come from the players lined up across from him.Garrett and Young are expected to face San Francisco’s veteran offensive tackles Trent Williams and Colton McKivitz. Williams, a perennial Pro Bowl presence, will have the difficult task of containing Garrett while helping protect the 49ers’ quarterback.That battle could shape the game. Garrett can change a drive with one explosive rush, while Williams brings years of experience against elite pass rushers.

San Francisco is also expecting Nick Bosa and George Kittle to return after lengthy injury recoveries, although coach Kyle Shanahan has not confirmed how much they will play.The game carries plenty of intrigue beyond the unusual location. The Rams are viewed as Super Bowl contenders, while the 49ers also expect to challenge for the NFC crown.For Garrett, though, the mission is more personal. After making his name as one of football’s most feared pass rushers, he now gets his first chance to establish himself as the centerpiece of the Rams defense.And there may be no better stage for that introduction than Australia.

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It was published on September 10, 2026 and last updated on October 9, 2026. The time of the story is shown in your own time zone on the page.

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